Medication plays an important role in managing lipodystrophy and the health problems that can occur alongside it. Lipodystrophy affects the way the body stores and uses fat, which can lead to insulin resistance, abnormal blood fats and excess fat in the liver. Treatment is highly individual and is best managed by a specialist team experienced in lipodystrophy care.
Metreleptin
Metreleptin (Myalepta) is a synthetic form of the hormone leptin and may be suitable for some people with lipodystrophy, particularly those with generalised forms of the condition. It can help improve blood glucose control, reduce triglyceride levels and lessen fat accumulation in the liver in some patients.
Metreleptin is prescribed and monitored by specialist centres in the UK and is given as a daily subcutaneous injection. Your specialist team will discuss whether it is appropriate for you and will provide advice on its safe use and ongoing monitoring.
Medicines for Insulin Resistance and Diabetes
Many people with lipodystrophy develop insulin resistance or type 2 diabetes. Treatment is tailored to each person and may include:
- Metformin, which helps the body respond more effectively to insulin.
- GLP-1 receptor agonists, which support blood glucose control and can reduce appetite and body weight. Evidence for their use in lipodystrophy is emerging, and suitability will depend on individual circumstances.
- Insulin therapy, if other medicines are not sufficient to maintain stable glucose levels.
Your healthcare team will review your progress regularly to ensure that treatment remains effective and well tolerated.
Medicines for High Lipids and Fatty Liver
Lipodystrophy can lead to high triglyceride levels and fatty liver disease. These may be managed with:
- Fibrates or prescription omega-3 supplements to help lower triglyceride levels and reduce the risk of pancreatitis.
- Statins to manage cholesterol levels and protect heart health.
- Ongoing monitoring of liver function to identify and manage any signs of fatty liver or inflammation.
Lifestyle measures, such as maintaining a balanced diet and regular physical activity, remain important alongside medication.
Other Treatments and Supplements
Depending on your individual needs, your specialist may recommend other treatments, including:
- Hormone replacement therapy if hormone levels are low.
- Blood pressure medication to protect cardiovascular and kidney health.
- Vitamin or mineral supplements if deficiencies are identified.
All treatments should be discussed and coordinated through your specialist team.
Working with Your Healthcare Team
Lipodystrophy is a rare condition and care is most effective when managed by a multidisciplinary specialist team. They will monitor your response to treatment, adjust medicines as required, manage potential side effects and coordinate care for any related conditions.
You should never start, stop or change your medication without medical advice. If you have any concerns, speak with your healthcare provider.
